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US 5,782,792 AGranted
Method for treatment of rheumatoid arthritis
AssigneeCypress Bioscience, Inc.
InventorsFrank R. Jones, Harry W. Snyder, Jr., Joseph P. Balint, Jr.
Life of this patent
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Abstract
Rheumatoid arthritis is treated by the extra corporeal removal of IgG and IgG-containing circulating immune complexes from the patient's blood. Removal is preferably accomplished by exposing the blood or blood plasma to a protein A immunoadsorbent which binds to IgG-containing immune complexes with high affinity.
Claims13
A method for treating a patient suffering from rheumatoid arthritis, consisting essentially of
- (A) removing blood from the patient and separating cellular components therefrom to provide a cellular-component volume and a plasma volume,
- (B) contacting the plasma volume with an immunoadsorbent to effect removal of immunoglobulin G and immune complexes, wherein the immunoadsorbent comprises an inert carrier and protein A bound thereto, and then
- (C) mixing and returning directly to the patient the cellular-component volume and the immunoadsorbent-treated plasma volume from step (B), wherein step (C) is effected while step (A) is still being carried out.
Dependencies are inferred from the claim text.