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US 5,780,512 AGranted
Alkylated (hetero) cyclic compounds
AssigneeAdir et Compagnie
InventorsDaniel Lesieur, Eric Fourmaintraux, Patrick Depreux, Philippe Delagrange, Pierre Renard, Beatrice Guardiola-Lemaitre
Life of this patent
Estimating the term…
Abstract
The invention relates to a compounds selected from these of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3 and A are as defined in the description, and a medicinal product containing the same useful for treating a melatoninergic disorder.
Claims9
A compound selected from those of formula (I):
- ##STR55## in which:
- R.sub.1 represents a group chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, and substituted cycloalkylalkyl,
- A forms, with the benzene ring to which it is attached, a cyclic group chosen from tetrahydronaphthalene, dihydronaphthalene, and naphthalene,
- R.sub.2 represents hydrogen or alkyl,
- R.sub.3 represents:
- a group R.sub.31 :
- ##STR56## with X representing sulfur or oxygen and R.sub.4 representing a group R.sub.41 chosen from alkyl, substituted alkyl, alkenyl, alkynyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, and substituted cycloalkylalkyl,
- or a group of formula (R.sub.32):
- ##STR57## with X' representing sulfur or oxygen and R.sub.5 representing hydrogen or group chosen from alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloalkylalkyl, and substituted cycloalkylalkyl,
- it being understood that in the description of formula (I), and except where otherwise mentioned:
- the term "alkyl" denotes a linear or branched group containing 1 to 6 carbon atoms, inclusive,
- the terms "alkenyl" and "alkynyl" denote linear or branched groups containing 2 to 6 atoms, inclusive,
- the term "cycloalkyl" denotes a group of 3 to 8 carbon atoms, inclusive,
- the term "substituted" associated with the alkyl group means that this group is substituted with one or more substituents chosen from halogen, alkyl, hydroxyl, and alkoxy, containing 1 to 6 carbon atoms, inclusive,
- the term "substituted" associated with the "cycloalkyl" and "cycloalkylalkyl" group means that this group is substituted with one or more groups chosen from halogen, alkyl, and oxo,
- and the enantiomers and diastereoisomers thereof.
13 more elements
Dependencies are inferred from the claim text.