2,4-disulfo phenyl butyl nitrone, its salts and their use as pharmaceuticals
AssigneesOklahoma Medical Research Foundation, University of Kentucky Research Foundation
InventorJohn M. Carney
Life of this patent
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Abstract
2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.
Claims40
A method for treating a patient who has suffered a concussion comprising administering to said patient an effective concussion treating amount of a pharmaceutical composition comprising the compound 2,4-disulfo alpha-phenyl tertiary butyl nitrone in a pharmaceutically acceptable carrier.
A method for treating a patient who has suffered a concussion comprising administering to said patient an effective concussion treating amount of a pharmaceutical composition comprising a compound of the formula:
- ##STR15## in a pharmaceutically acceptable carrier.
A method for treating a patient who has suffered a concussion comprising administering to said patient an effective concussion treating amount of a pharmaceutical composition comprising a pharmaceutically acceptable salt of:
- ##STR16## in a pharmaceutically acceptable carrier.
A method for treating a patient who has suffered a concussion comprising administering to said patient an effective concussion treating amount of a pharmaceutical composition comprising a compound of the formula:
- ##STR17## wherein X is selected from the group consisting of Na, K, NH.sub.4, Ca, Mg, Zn, ZnY, CaY and MgY, wherein Y is a pharmaceutically acceptable monovalent anion, in a pharmaceutically acceptable carrier.
A method for treating a patient who is suffering from a subarachnoid hemorrhage comprising administering to said patient an effective subarachnoid hemorrhage treating amount of a pharmaceutical composition comprising the compound 2,4-disulfo alpha-phenyl tertiary butyl nitrone in a pharmaceutically acceptable carrier.
A method for treating a patient who is suffering from a subarachnoid hemorrhage comprising administering to said patient an effective subarachnoid hemorrhage treating amount of a pharmaceutical composition comprising a compound of the formula:
- ##STR18## in a pharmaceutically acceptable carrier.
A method for treating a patient who is suffering from a subarachnoid hemorrhage comprising administering to said patient an effective subarachnoid hemorrhage treating amount of a pharmaceutical composition comprising a pharmaceutically acceptable salt of:
- ##STR19## in a pharmaceutically acceptable carrier.
A method for treating a patient who is suffering from a subarachnoid hemorrhage comprising administering to said patient an effective subarachnoid hemorrhage treating amount of a pharmaceutical composition comprising a compound of the formula:
- ##STR20## wherein X is selected from the group consisting of Na, K, NH.sub.4, Ca, Mg, Zn, ZnY, CaY and MgY, wherein Y is a pharmaceutically acceptable monovalent anion, in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.