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US 5,780,466 AGranted
Substituted heterocyclic compounds method of preparing them and pharmaceutical compositions in which they are present
AssigneeSanofi
InventorsXavier Emonds-Alt, Isabelle Grossriether, Patrick Gueule, Vincenzo Proietto, Didier Van Broeck, Joelle Taillades
Life of this patent
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Abstract
The invention relates to compounds of the formula ##STR1## in which: A is a divalent radical selected from: A.sub.1) --O--CO-- A.sub.2) --CH.sub.2 --O--CO-- A.sub.3) --O--CH.sub.2 --CO-- A.sub.4) --O--CH.sub.2 --CH.sub.2 -- A.sub.5) --N(R.sub.1)--CO-- A.sub.6) --N(R.sub.1)--CO--CO-- A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 -- A.sub.8) --O--CH.sub.2 -- in which: R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl; and Am is a nitrogen-containing heterocycle.
Claims10
A compound of the formula ##STR129## in which:
- A is a divalent radical selected from:
- A.sub.1) --O--CO--
- A.sub.2) --CH.sub.2 --O--CO--
- A.sub.3) --O--CH.sub.2 --CO--
- A.sub.4) --O--CH.sub.2 --CH.sub.2 --
- A.sub.5) --N(R.sub.1)--CO--
- A.sub.6) --N(R.sub.1)--CO--CO--
- A.sub.7) --N(R.sub.1)--CH.sub.2 --CH.sub.2 --
- A.sub.8) --O--CH.sub.2 --
- in which R.sub.1 is a hydrogen or a (C.sub.1 -C.sub.4)-alkyl;
- m is 2 or 3;
- Ar.sub.1 is a phenyl which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a hydroxyl, a (C.sub.1 -C.sub.4)-alkoxy, a (C.sub.1 -C.sub.4)-alkyl, a trifluoromethyl and a methylenedioxy, said substituents being identical or different;
- a thienyl which is unsubstituted or substituted by a halogen atom;
- a benzothienyl which is unsubstituted or substituted by a halogen atom;
- a naphthyl which is unsubstituted or substituted by a halogen atom;
- an indolyl which is unsubstituted or N-substituted by a (C.sub.1 -C.sub.4)-alkyl or a benzyl;
- an imidazolyl which is unsubstituted or substituted by a halogen atom;
- a pyridyl which is unsubstituted or substituted by a halogen atom;
- or a biphenyl;
- T is a group selected from CH.sub.2 --Z, --CH(C.sub.6 H.sub.5).sub.2 and --C(C.sub.6 H.sub.5).sub.3 ;
- T can also be the group --CO--B--Z if A is a divalent radical selected from --O--CH.sub.2 --CH.sub.2 --, --N(R.sub.1)--CH.sub.2 --CH.sub.2 -- and --O--CH.sub.2 --;
- B is a direct bond or a methylene;
- Z is an optionally substituted mono-, di- or tricyclic aromatic or heteroaromatic group;
- and
- Ar.sub.2 is a pyridyl;
- a phenyl which is unsubstituted or monosubstituted or polysubstituted by a substituent selected from a halogen atom, a hydroxyl, a (C.sub.1 -C.sub.4)-alkoxy, a (C.sub.1 -C.sub.4)-alkyl, a trifluoromethyl, a nitro and a methylenedioxy, said substituents being identical or different;
- a thienyl;
- a pyrimidyl;
- or an imidazolyl which is unsubstituted or substituted by a (C.sub.1 -C.sub.4)-alkyl;
- and
- Am is:
- (i) a group Am.sub.4 of the formula ##STR130## in which:
- Ar.sub.2 is as defined above;
- n is 0 or 1;
- and
- X.sup..crclbar. is an anion;
- and the salts thereof with mineral or organic acids.
34 more elements
Dependencies are inferred from the claim text.