Water soluble rapamycin esters
AssigneeAmerican Home Products Corporation
InventorsHyuk-Koo Lee, Tianmin Zhu
Life of this patent
Estimating the term…
Abstract
A compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or COCH.sub.2 --S--CH.sub.2 CH.sub.2 --O--CH.sub.2 --(CH.sub.2 OCH.sub.2).sub.n --CH.sub.2 --O--CH.sub.2 CH.sub.2 --OCH.sub.3 ; and n=8-450; with the proviso that R.sup.1 and R.sup.2 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
Claims9
A compound of the structure ##STR4## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --COCH.sub.2 --S--CH.sub.2 CH.sub.2 --O--CH.sub.2 --(CH.sub.2 OCH.sub.2).sub.n --CH.sub.2 --O--CH.sub.2 CH.sub.2 --OCH.sub.3 ;
- and n=8-450;
- with the proviso that R.sup.1 and R.sup.2 are not both hydrogen.
A pharmaceutical composition which comprises a compound of the structure ##STR5## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or --COCH.sub.2 --S--CH.sub.2 CH.sub.2 --O--CH.sub.2 --(CH.sub.2 OCH.sub.2).sub.n --CH.sub.2 --O--CH.sub.2 CH.sub.2 --OCH.sub.3 ;
- and n=8-450;
- with the proviso that R.sup.1 and R.sup.2 are not both hydrogen, and a pharmaceutical carrier.
Dependencies are inferred from the claim text.