DNA-based vaccination of fish
AssigneeOttawa Civic Hospital Loeb Research
InventorHeather L. Davis
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Abstract
The present invention relates to methods of immunization of aquaculture species by introducing DNA expression systems into the aquaculture species. Such DNA expression systems preferably include DNA sequences encoding polypeptides of pathogens of species of aquaculture. The present invention also relates to methods of administration of DNA expression systems into aquaculture. Such methods include injection, spray, and immersion techniques. The methods of this invention are useful for prophylactic vaccination or therapeutic immunization of fin-fish, shellfish, or other aquatic animals against infectious diseases.
Claims83
A composition for inducing an immune response in finfish comprising:
- an expression vector having an expression control sequence capable of directing expression in finfish of at least one immunogenic polypeptide and a polypeptide-encoding DNA sequence encoding at least one immunogenic polypeptide from a fish pathogen.
A method of inducing immune response in fin-fish against infection from fish pathogens, comprising administering to the fin-fish a composition for inducing an immune response comprising an expression vector having an expression control sequence capable of directing expression of an immunogenic polypeptide, and a polypeptide-encoding DNA sequence encoding an immunogenic polypeptide.
A method for expressing a polypeptide in fin-fish comprising administering to a fin-fish a DNA expression vector comprising an expression control sequence capable of directing expression of a polypeptide and a polypeptide-encoding DNA sequence encoding at least one polypeptide from a fish pathogen.
Dependencies are inferred from the claim text.