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US 5,780,050 AGranted
Drug delivery compositions for improved stability of steroids
AssigneeTheratech, Inc.
InventorsUday Jain, Srinivasan Venkateshwaran, Charles D. Ebert
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AssigneeTheratech, Inc.
InventorsUday Jain, Srinivasan Venkateshwaran, Charles D. Ebert
Estimating the term…
A stabilized patch device for transdermal drug delivery of steroid drugs containing a 3-keto-4-en functional group is described, wherein the patch comprises an effective amount of the steroid drug and a carrier that is free of acid functional groups. The device can further contain additives such as a penetration enhancer or excipient, so long as such additives are also free of acid functional groups. The device can be either a matrix patch or a liquid reservoir patch. In a matrix patch, the carrier is a biocompatible polymeric adhesive with which the steroid drug is intimately admixed. The adhesive is preferably an acrylic polymer or copolymer. In a liquid reservoir patch, the carrier is a controlled-viscosity composition containing a thinner or thickener. Preferred steroid drugs include certain corticosteroids and sex hormones, such as progestins and androgens. A method of stabilizing such steroid drugs during storage in transdermal patches is also disclosed.
A stabilized patch device for transdermal delivery of a steroid drug containing a 3-keto-4-en functional group, wherein said steroid drug is stable upon storage of said device, comprising an effective amount of said steroid drug and a biocompatible polymeric adhesive with which said steroid drug is intimately admixed, wherein said polymeric adhesive is a block copolymer of N-vinyl pyrrolidone and 2-ethyl-hexyl acrylate.
A method of stabilizing a steroid drug containing a 3-keto-4-en functional group during storage of a transdermal drug delivery patch device containing said steroid drug comprising the steps of (a) first intimately admixing an effective amount of said steroid drug with an effective amount of a block copolymer of N-vinyl pyrrolidone and 2-ethyl-hexyl acrylate, and (b) then incorporating said admixed steroid drug and block copolymer of N-vinyl pyrrolidone and 2-ethyl-hexyl acrylate into said delivery patch device as a source of said steroid drug.
Dependencies are inferred from the claim text.