US 5,780,044 AGranted

Liquid delivery compositions

AssigneeAtrix Laboratories, Inc.

InventorsGerald L. Yewey, Nancy L. Krinick, Richard L. Dunn, Michael L. Radomsky, Gerbrand Brouwer, Arthur J. Tipton

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Abstract

Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

Claims15

Dependent claims

A delivery composition suitable for in situ formation of a solid implant for controlled release of an active agent, the composition comprising:

(a) a biocompatible organic solvent which has a solubility range of miscible to dispersible in aqueous medium;
(b) a biocompatible, biodegradable, thermoplastic polymer dissolved in the organic solvent, the thermoplastic polymer being insoluble in aqueous medium;
and
(c) an active agent incorporated into a particulate controlled release component, the particulate controlled release component being suspended in the organic solvent wherein upon contacting an aqueous medium, the organic solvent dissipates or
disperses into the aqueous medium and the thermoplastic polymer precipitates or coagulates to form the solid implant in which the particulate controlled release component is embedded.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 08/761,015Filed 5 Dec 1996 · continuation
Priority: 8 Apr 1994
Granted: 14 Jul 1998
Term ends: Not estimatedThe source records don’t support an estimate.

Classification43 codes

A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 9/10
Medicinal preparations characterised by special physical form: dispersions; Emulsions
A61K 9/146
Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried,…: with…
A61K 9/5026
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates