Phosphocholines of retinoids
AssigneeClarion Pharmaceuticals Inc.
InventorsAndrew C. Peterson, Haridasan K. Nair
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Abstract
Novel retinoid phosphocholines are disclosed having the general Formula (I): ##STR1## wherein R represents a retinyl or retinoyl moiety. The optical and geometric isomers of compounds of Formula (I) and the pharmaceutically-acceptable salts thereof, are also disclosed. The subject compounds exhibit anti-tumor, anti-psoriatic and anti-inflammatory activities in addition to their inherent Vitamin A-like activities. The invention embraces the novel compounds, pharmaceutical compositions thereof, and methods of using the same.
Claims19
A retinyl- or retinoylphosphocholine selected from the group consisting of Formula (I) compounds:
- ##STR6## wherein R represents a retinyl or retinoyl moiety, and pharmaceutically-acceptable salts thereof.
A method of treating inflammation, tumors, or psoriasis in a mammal which comprises administering to the mammal an effective anti-inflammatory, anti-tumor or anti-psoriatic amount, respectively, of one or more retinyl- or retinoylphosphocholines selected from the group consisting of formula (I) compounds:
- ##STR7## wherein R represents a retinyl moiety, and pharmaceutically-acceptable salts thereof.
A method of treating inflammation in a mammal which comprises administering to the mammal an effective anti-inflammatory amount of one or more retinyl- or retinoylphosphocholines selected from the group consisting of Formula (I) compounds:
- ##STR8## wherein R represents a retinyl or retinoyl moiety, and pharmaceutically-acceptable salts thereof.
A method of treating a tumor in a mammal which comprises administering to the mammal an effective anti-tumor amount of one or more retinyl- or retinoylphosphocholines selected from the group consisting of Formula (I) compounds:
- ##STR9## wherein R represents a retinyl or retinoyl moiety, and pharmaceutically-acceptable salts thereof.
A method of treating psoriasis in a mammal which comprises administering to the mammal an effective anti-psoriatic amount of one or more retinyl- or retinoylphosphocholines selected from the group consisting of Formula (I) compounds:
- ##STR10## wherein R represents a retinyl or retinoyl moiety, and pharmaceutically-acceptable salts thereof.
A pharmaceutical composition comprising an effective anti-inflammatory, anti-tumor, or anti-psoriatic amount of one or more retinyl- or retinoylphosphocholines selected from the group consisting of Formula (I) compounds:
- ##STR11## wherein R represents a retinyl or retinoyl moiety, and pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.