Method and kit for imaging and treating organs and tissues
AssigneeImmunomedics, Inc.
InventorMilton David Goldenberg
Life of this patent
Estimating the term…
Abstract
Provided are methods and compositions for detecting and treating normal, hypoplastic, ectopic or remnant tissue, organ or cells in a mammal. The method comprises parenterally injecting a mammalian subject, at a locus and by a route providing access to said tissue or organ, with an composition comprising antibody/fragment which specifically binds to targeted organ, tissue or cell. The antibody/fragment may be administered alone, or labeled or conjugated with an imaging, therapeutic, cytoprotective or activating agent.
Claims22
A method of imaging anatomically displaced organs or ectopic cells or tissues in a mammalian subject by scintigraphic or magnetic resonance imaging, comprising (a) parenterally injecting a mammalian subject, at a locus and by a route providing access to an organ or to cells or tissues characteristic of said organ of interest, with an antibody or antibody fragment which specifically binds a marker produced by or associated with said cells or tissues, said antibody or antibody fragment being labeled with a radioisotope or with a magnetic resonance image enhancing agent capable of external detection, the amount of the labeled antibody or antibody fragment being sufficient to permit a scintigraphic or an enhanced magnetic resonance image of said organ, cells or tissue to be obtained;
- and (b) obtaining a positive scintigraphic image or positive enhanced magnetic resonance image of said organ, cells or tissues, at a time after injection of said agent sufficient for said agent to specifically bind to said marker and, where it is desired to observe the anatomical position of an organ, to diffusely accrete in said organ.
A method of imaging a hypoplastic organ or hypoplastic cells or tissues in a mammalian subject by scintigraphic or magnetic resonance imaging, comprising (a) parenterally injecting a mammalian subject, at a locus and by a route providing access to an organ or to cells or tissues of interest, with an antibody or antibody fragment which specifically binds a marker produced by or associated with said cells or tissues, said antibody or antibody fragment being labeled with a radioisotope or with a magnetic resonance image enhancing agent capable of external detection, the amount of the labeled antibody or antibody fragment being sufficient to permit a scintigraphic or an enhanced magnetic resonance image of said organ, cells or tissues be obtained;
- and (b) obtaining a positive scintigraphic image or positive enhanced magnetic resonance image of said organ, cells or tissues, at a time after injection of said agent sufficient for said agent to specifically bind to said marker and, where it is desired to observe hypoplasia of an organ, to diffusely accrete in said organ.
Dependencies are inferred from the claim text.