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US 5,773,594 AGranted
Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity
AssigneeAllergan, Inc.
InventorsAlan T. Johnson, Min Teng, Vidyasagar Vuligonda, Richard L. Beard, Samuel J. Gillett, Tien T. Duong, Roshantha A. Chandraratna
Life of this patent
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Abstract
Compounds of the formula ##STR1## where the symbols have the meaning described in the application, have retinoid-like or retinoid antagonist-like biological activity.
Claims11
A compound of the formula ##STR29## where Z is C(CH.sub.3).dbd.CH--CH.dbd.CH--C(CH.sub.3).dbd.CH--, --N.dbd.N--, CO--CH.dbd.CH, or COO;
- Y is phenyl or when Z is C(CH.sub.3).dbd.CH--CH.dbd.CH--C(CH.sub.3).dbd.CH-- then Y represents a direct valence bond between Z and CO.sub.2 R.sub.8,
- R.sub.8 is hydrogen or lower alkyl, and
- R.sub.14 is CH.sub.2 COOR.sub.8, 2-thiazolyl or 2-thienyl, or a pharmaceutically acceptable salt of said compound.
Dependencies are inferred from the claim text.