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US 5,773,592 AGranted
Pro drugs for selective drug delivery
OwnerRandell Lee Millsinventor
Life of this patent
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Abstract
A broad class of pharmaceutical agents which react directly with electron carriers or with reactive species produced by electron transport to release a pharmacologically active molecule to effect a therapeutic functional change in the organism by a receptor or nonrecepter mediated action.
Claims26
A chemical compound having the formula A-B-C, where
- A is a chemiluminescent moiety which reacts with peroxides and oxygen free radicals and is capable of transferring energy from its own excited state to B;
- B is a photochromic moiety covalently bonded to A which receives energy from A to achieve an excited state, wherein the emission spectrum of A overlaps the absorption-release reaction spectrum of B in the wavelength range of 250 nm to 420 nm;
- and
- C is a biologically active agent covalently bonded to B, wherein relaxation of the excited state of B causes heterolytic cleavage of the covalent bond between B and C, thereby releasing C from B.
1 more element
A chemical compound having the formula A-B-C, where
- A is a chemiluminescent moiety which undergoes an oxidation reduction reaction and is capable of transferring energy from its own excited state to B;
- B is a photochromic moiety covalently bonded to A which receives energy from A to achieve an excited state, wherein the emission spectrum of A overlaps the absorption-release reaction spectrum of B in the wavelength range of 250 nm to 420 rnm;
- and
- C is a biologically active agent covalently bonded to B, wherein relaxation of the excited state of B causes heterolytic cleavage of the covalent bond between B and C, thereby releasing C from B.
1 more element
A chemical compound having the formula A-B-C, where
- A is a phthalhydrazide capable of transferring energy from its own excited state to B;
- B is a polymethine dye covalently bonded to A which receives energy from A to achieve an excited state, wherein the emission spectrum of A overlaps the absorption-release reaction spectrum of B in the wavelength range of 250 nm to 420 nm;
- and
- C is a biologically active agent covalently bonded to B, wherein relaxation of the excited state of B causes heterolytic cleavage of the covalent bond between B and C, thereby releasing C from B.
1 more element
Dependencies are inferred from the claim text.