Indane and tetrahydronaphthalene derivatives as calcium channel antagonists

Method of treatment of a condition or disease related to the accumulation of calcium in the brain cells of a mammal which comprises administering to a subject in need thereof an effective amount of a compound of formula (I):

• ##STR16## wherein X represents O, S or NH;
• R.sup.1 and R.sup.2 each independently represent hydrogen, C.sub.1-6 alkyl, C.sub.3-6 cycloalkyl, or C.sub.1-4 alkyl-C.sub.3-6 cycloalkyl;
• n is 1, 2 or 3;
• and
• Ar represents an phenyl optionally substituted by 1 to 3 substituents selected from:
• halo, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, C.sub.1-2 alkylenedioxy, trifluoromethyl, trifluoromethoxy, CN, NO.sub.2, amino, mono- or di-alkylamino, optionally substituted benzoyl and Ph(CH.sub.2).sub.r Y(CH.sub.2).sub.s -- where Ph is optionally substituted phenyl, Y is oxygen or a bond and r and s each independently represent 0-4 provided that the sum of r+s is not greater than 4, or
• Ar represents an optionally substituted unsaturated monocyclic heteroaryl ring system containing 5 or 6 ring members, or an optionally substituted, unsaturated or partially saturated bicyclic aryl or heteroaryl ring system containing 8-10 ring members,
• or a pharmaceutically acceptable salt thereof.