Immune reactivity to expressed activated oncogenes for diagnosis and treatment of malignancy
AssigneeWashington Research Foundation
InventorsMartin A. Cheever, David J. Peace
Life of this patent
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Abstract
Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes formed between the protein expression product and antibodies in body fluid, allows the diagnosis of the presence of a malignancy. The present invention also discloses methods and compositions for treating a malignancy.
Claims3
A method for the detection of a malignancy in a warm-blooded animal, wherein an activated oncogene or cancer-related gene is associated with the malignancy, comprising the steps of:
- (a) isolating T cells from a warm-blooded animal;
- (b) incubating the T cells with at least one protein expression product of an activated oncogene or cancer-related gene associated with the malignancy the product having an altered primary sequence;
- and
- (c) detecting the presence or absence of proliferation of the T cells, thereby determining the presence or absence of the malignancy.
Dependencies are inferred from the claim text.