Hammerhead-like nucleic acid analogues and their synthesis
AssigneeToagosei Co., Ltd.
InventorsHiroshi Sugiyama, Ken Hatano, Isao Saito, Takayoshi Uchida, Yoko Matsuda, Kiyoshi Uchida
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Abstract
The present invention provides nucleic acid compounds which have a non-nucleic acid structure with ring skeleton to which two functional groups are bound with fixed state and are able to point to substantially the same direction, nucleic acid compounds which can form triple strands with third nucleotide chains, nucleic acid compounds which have improved permeability, and synthetic methods thereof.
Claims15
A nucleic acid compound which has a moiety of a non-nucleic acid structure with a ring skeleton to which two functional groups are bound with a fixed conformation and are able to point to substantially the same direction, and a moiety of a pair of nucleotide chains which are bound to the functional groups.
A synthetic method for making a nucleic acid compound, said method comprising:
- (a) introducing a protecting group into one hydroxyl group of non-nucleic acid compound with a ring skeleton to which two hydroxyl groups are bound with a fixed conformation and are able to point to substantially the same direction;
- (b) binding the other hydroxyl group of said compound to the first nucleotide chain of a pair of nucleotide chains;
- (c) removing said protecting group of the compound;
- and
- (d) binding the deblocked hydroxyl group of the compound to the second nucleotide chain of said pair of nucleotide chains.
Dependencies are inferred from the claim text.