Chlamydia major outer membrane protein
AssigneesWashington Research Foundation, Chiron Corporation
InventorsNina Agabian, Richard Stephens, Cho-Chou Kuo, Guy Mullenbach
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Abstract
Methods and compositions are provided for the production of a polypeptide which is immunologically cross-reactive with a naturally-occurring major outer membrane protein (MOMP) of Chlamydia trachomatis. A DNA construct including a replication system recognized by E. coli, and an MOMP gene under the transcriptional control of a .beta.-galactosidase promoter and terminator is provided. Recombinant phage .lambda.gt11/L2/33 was deposited at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Md. 20852, on Jan. 10, 1985 and granted accession no. 40157. L2 B9-F DNA was deposited at the American Type Culture Collection on Dec. 31, 1985, and granted accession No. 40217.
Claims13
A DNA construct comprising a first DNA sequence segment encoding a polypeptide of at least 12 amino acids of the Chlamydia trachomatis major outer membrane protein (MOMP), operably linked to additional DNA sequence segments required for the expression of said first DNA sequence segment.
An isolated polynucleotide encoding a polypeptide of at least 12 amino acids of the Chlamydia trachomatis major outer membrane protein (MOMP).
Dependencies are inferred from the claim text.