Polymers for delivering nitric oxide in vivo
AssigneeDuke University Medical Center
InventorsJonathan S. Stamler, Eric J. Toone, Richard S. Stack
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Abstract
Disclosed are novel polymers derivatized with at least one --NO.sub.X group per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.
Claims34
An S-nitrosylated polysaccharide having at least one --S--NO group per 1200 atomic mass units.
A cyclic S-nitrosylated polysaccharide having at least one --S--NO group per 1200 atomic mass units.
A polymer prepared by reacting a solution comprising a polythiolated polysaccharidc with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups.
A method of preparing a cyclic S-nitrosylated polysaccharide comprising reacting a cyclic polythiolated polysaccharide with a nitrosylating agent under conditions suitable for nitrosylating tree thiol groups.
An S-nitrated cyclic polysaccharide having at least one --S--NO.sub.2 group per 1200 atomic mass unit.
A polymer prepared by reacting a solution comprising a cyclic polythiolated polysaccharide with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups.
A method of preparing an S-nitrosylated polysaccharide comprising reacting a polythiolated polysaccharide with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups.
Dependencies are inferred from the claim text.