Method of treating hepatitis virus infections
AssigneesWake Forest University, University of North Carolina
InventorsLouis S. Kucera, Susan L. Morris-Natschke
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Abstract
A method of treating hepatitis virus infection is disclosed. The method comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of an alkyl lipid or alkyl lipid derivative.
Claims14
A method of treating a hepatitis B virus infection comprising administering to a human subject in need of such treatment an effective hepatitis virus-combatting amount of a compound of Formula I;
- ##STR7## wherein Y is S, O, NH, NCH.sub.3, NHC(O), or NCH.sub.3 C(O);
- R.sub.1 is unbranched or branched, saturated or unsaturated C 14-C18 alkyl, alkenyl, or alkynyl;
- X is a covalent bond or methylene optionally substituted with hydroxyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio or C1-C20 alkylamido;
- and D is selected from the group consisting of moieties of Formula V or Formula VI;
- wherein Formula V is
- -(PO.sub.4).sup.13 -E (V)
- wherein E is -J-N.sup.+ (R.sub.2)(R.sub.3)(R.sub.4), wherein J is C1 -C4 alkyl optionally substituted one to three times with methyl or ethyl;
- and R.sub.2, R.sub.3, and R.sub.4 are independently selected from the group consisting of H and C1-C3 alkyl;
- or a pharmaceutical salt thereof.
A method of treating a hepatitis B viral infection comprising administering a human subject in need of such treatment an effective hepatitis B virus-combatting amount of a compound of Formula II:
- ##STR8## wherein Y is S, O, NH, NCH.sub.3, NHC(O), or NCH.sub.3 C(O);
- R.sub.1 is an unbranched or branched, saturated or unsaturated C14-C18 alkyl, alkenyl, or alkynyl;
- X is a covalent bond or methylene optionally substituted with hydroxyl, C1-C20 alkyl, C1-C20 alkoxy, C1-C20 alkylthio or C1-C20 alkylamido;
- J is C1-C4 alkyl optionally substituted one to three times with methyl or ethyl;
- and R.sub.2, R.sub.3, and R.sub.4 are independently selected from the group consisting of H and C1-C3 alkyl;
- or a pharmaceutical salt thereof.
Dependencies are inferred from the claim text.