Cloning and exprssion of humanized monoclonal antibodies against human interluekin-4
AssigneeSchering Corporation
InventorsBarbara Dalie, Hung V. Le, Kenneth Miller, Nicholas J. Murgolo, Hanh Nguyen, Stephen Tindall, Paul J. Zavodny
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Abstract
Monoclonal antibodies are provided which are specific for human interleukin-4. Also provided are complementary DNAs which encode the heavy and light chain variable regions of such monoclonal antibodies and complementarity determining regions from such DNAs; and kits and methods for detecting, measuring and immunopurifying human interleukin-4, and for blocking the biological activity of human interleukin-4.
Claims4
A nucleic acid which encodes a humanized antibody which comprises a variable region having the amino acid sequence of an antibody, selected from the group consisting of h25D2L-1, h25D2hH-1, h25D2H-2, h25D2H-3, h252H-4, and h25D2H-5.
Dependencies are inferred from the claim text.