Therapeutic drug delivery systems
AssigneeImaRx Pharmaceutical Corp.
InventorsEvan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
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Abstract
Therapeutic drug delivery systems comprising gas-filled microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic drug delivery applications are also provided. Drug delivery systems comprising gas-filled liposomes having encapsulated therein a drug are preferred. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in drug delivery applications are also disclosed.
Claims75
A targeted therapeutic delivery system comprising a gas-filled lipid-containing microsphere wherein said gas-filled microsphere has an interior volume of at least about 50% gas, and comprises a therapeutic compound wherein said therapeutic compound is selected from the group consisting of antineoplastic agents;
- blood products;
- biological response modifiers;
- anti-fungal agents;
- hormones;
- vitamins;
- peptides;
- anti-tuberculars;
- enzymes;
- anti-allergic agents;
- anti-coagulation agents;
- circulatory drugs;
- metabolic potentiators;
- antivirals;
- antianginals;
- antibiotics;
- antiinflammatories;
- antiprotozoans;
- antirheumatics;
- narcotics;
- opiates;
- cardiac glycosides;
- neuromuscular blockers;
- sedatives;
- local anesthetics;
- general anesthetics;
- radioactive compounds;
- monoclonal antibody;
- genetic material;
- prodrugs;
- and combinations thereof.
A drug delivery system comprising a gas-filled liposome prepared by a vacuum drying gas instillation method and having encapsulated therein a drug, wherein said gas-filled liposome has an interior volume of at least about 50% gas, and wherein said drug is selected from the group consisting of antineoplastic agents;
- blood products;
- biological response modifiers;
- anti-fungal agents;
- hormones;
- vitamins;
- peptides;
- anti-tuberculars;
- enzymes;
- anti-allergic agents;
- anti-coagulation agents;
- circulatory drugs;
- metabolic potentiators;
- antivirals;
- antianginals;
- antibiotics;
- antiinflammatories;
- antiprotozoans;
- antirheumatics;
- narcotics;
- opiates;
- cardiac glycosides;
- neuromuscular blockers;
- sedatives;
- local anesthetics;
- general anesthetics;
- radioactive compounds;
- monoclonal antibody;
- genetic material;
- prodrugs and combinations thereof.
A drug delivery system comprising a gas-filled liposome wherein said gas-filled liposome has an interior volume of at least about 50% gas and comprises a drug encapsulated therein, wherein said drug is selected from the group consisting of antineoplastic agents;
- blood products;
- biological response modifiers;
- anti-fungal agents;
- hormones;
- vitamins;
- peptides;
- anti-tuberculars;
- enzymes;
- anti-allergic agents;
- anti-coagulation agents;
- circulatory drugs;
- metabolic potentiators;
- antivirals;
- antianginals;
- antibiotics;
- antiinflammatories;
- antiprotozoans;
- antirheumatics;
- narcotics;
- opiates;
- cardiac glycosides;
- neuromuscular blockers;
- sedatives;
- local anesthetics;
- general anesthetics;
- radioactive compounds;
- monoclonal antibody;
- genetic material;
- prodrugs;
- and combinations thereof.
A drug delivery system prepared by a method comprising the steps of:
- (i) placing under negative pressure liposomes having encapsulated therein a drug, wherein said drug is selected from the group consisting of antineoplastic agents;
- blood products;
- biological response modifiers;
- anti-fungal agents;
- hormones;
- vitamins;
- peptides;
- anti-tuberculars;
- enzymes;
- anti-allergic agents;
- anti-coagulation agents;
- circulatory drugs;
- metabolic potentiators;
- antivirals;
- antianginals;
- antibiotics;
- antiinflammatories;
- antiprotozoans;
- antirheumatics;
- narcotics;
- opiates;
- cardiac glycosides;
- neuromuscular blockers;
- sedatives;
- local anesthetics;
- general anesthetics;
- radioactive compounds;
- monoclonal antibody;
- genetic material;
- prodrugs;
- and combinations thereof;
- (ii) incubating said liposomes under the negative pressure for a time sufficient to remove substantially all liquid from said liposomes;
- and
- (iii) instilling gas into said liposomes until ambient pressures are achieved to produce a drug delivery system comprising gas-filled liposomes having an interior volume of at least about 50% gas.
Dependencies are inferred from the claim text.