Glucose and lactate sensors
AssigneeChiron Diagnostics Corporation
InventorsThomas C. Maley, Mark W. Boden, Paul A. D'Orazio, Peter G. Edelman
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Abstract
A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered to a portion of the substrate. A first portion of the conductive material is covered with an electrically insulating dielectric coating, and a second portion of the conductive material is covered with an active layer. The active layer includes a catalytically active quantity of an enzyme carried by platinized carbon powder particles, which are distributed throughout the active layer. A sensor package for incorporating a sensor is provided.
Claims20
A reference electrode, comprising:
- a substrate layer:
- a cellulose acetate layer, formed from screen printing a paste which comprises:
- (a) cellulose acetate;
- and
- (b) an aprotic solvent, said paste having a viscosity of from about 40,000 centipose to about 350,000 centipoise;
- and
- a membrane disposed over said cellulose acetate layer.
A reference electrode, comprising:
- a substrate layer:
- a dielectric layer supported by said substrate layer:
- a silver-silver chloride layer supported by said substrate layer:
- a membrane supported by said substrate layer:
- and a cellulose acetate layer supported by said substrate layer, said cellulose acetate layer being formed from a cellulose acetate paste, comprising:
- (a) cellulose acetate;
- and
- (b) a solvent, said paste having a viscosity of from about 40,000 centipoise to about 350,000 centipoise.
A process for forming a reference electrode the process comprising the steps of:
- (a) providing a substrate layer, a dielectric layer supported by said substrate layer, a conductive strip supported by said substrate layer, and a silver-silver chloride layer supported by said conductive strip:
- (b) forming a paste by mixing cellulose acetate with a solvent;
- (c) forming a cellulose acetate layer by screen printing said paste on said silver-silver chloride layer;
- and
- (d) disposing a membrane over said cellulose acetate layer to provide said reference electrode.
Dependencies are inferred from the claim text.