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US 5,767,293 AGranted
Oxaspiro2,5! octane derivative
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTeruo Oku, Chiyoshi Kasahara, Takehiko Ohkawa, Masashi Hashimoto
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Abstract
Oxaspiro2,5! octanes of the formula ##STR1## inhibit angiogenesis and are particularly suitable for the treatment of solid tumors. In preferred embodiments, R.sup.1 is a carbamoyl derivative, R.sup.2 is an alkoxy substituent and R.sup.3 is ##STR2## Pharmaceutical salts of these compounds, such as methyl, amonium and organic amine salts also exhibit desirable properties.
Claims4
An oxaspiro2,5!octane derivative of the formula:
- ##STR19## wherein R.sup.1 is lower alkyl carbamoyl, R.sup.2 is methoxy and R.sup.3 is ##STR20## or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.