Asymmetric synthesis catalyzed by transition metal complexes with new chiral ligands
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
Life of this patent
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Abstract
A chiral ligand having the following structure: ##STR1## wherein AR is any aromatic and/or ring structure, and R is selected from the group consisting of aryl, oxygenated aryl, alkyl, oxygenated alkyl, AR, oxygenated AR and combinations thereof.
Claims35
A composition comprising about 90% to 100% of a first enantiomeric configuration of a chiral ligand and about 10% to 0% of at least one enantiomeric configuration of said chiral ligand different from said first enantiomeric configuration, said ligand having the following structure:
- ##STR61## wherein AR is any aromatic or ring structure, and R is selected from the group consisting of aryl, alkyl, aralkyl, ring-substituted aralkyl substituted aryl and combinations thereof.
A catalyst which comprises:
- a transition metal;
- and
- a composition comprising about 90% to 100% of a first enantiomeric configuration of a chiral ligand and about 10% to 0% of at least one enantiomeric configuration of said chiral ligand different from said first enantiomeric configuration, said ligand having the following structure:
- ##STR63## wherein AR is any aromatic or ring structure, and R is selected from the group consisting of aryl, alkyl, aralkyl, ring-substituted aralkyl, substituted aryl and combinations thereof.
A composition comprising about 90% to 100% of a first enantiomeric configuration of a chiral ligand and about 10% to 0% of at least one enantiomeric configuration of said chiral ligand different from said first enantiomeric configuration, said ligand having two chiral phosphine groups in transpositions and an aromatic backbone.
A composition comprising about 90% to 100% of a first enantiomeric configuration of a chiral ligand and about 10% to 0% of at least one enantiomeric configuration of said chiral ligand different from said first enantiomeric configuration, said ligand having the following structure:
- ##STR65## wherein AR is any aromatic or ring structure, R.sub.1 and R.sub.2 are different and are selected from the group consisting of aryl, alkyl, aralkyl, ring-substituted aralkyl, substituted aryl and combinations thereof, and n=1 or 2.
A chiral ligand having the following structure:
- ##STR66## wherein AR is any aromatic or ring structure, and R is selected from the group consisting of aryl, alkyl, aralkyl, ring-substituted aralkyl, substituted aryl and combinations thereof, wherein said ligand is bidentate and further comprises a pyridine nitrogen atom.
A chiral ligand having the following structure:
- ##STR67## wherein AR is any aromatic or ring structure, and R is selected from the group consisting of aryl, alkyl, aralkyl, ring-substituted aralkyl, substituted aryl and combinations thereof, and wherein said ligand is prepared by asymmetric reduction with chiral borane reducing agents.
Dependencies are inferred from the claim text.