Treatment of autonomic nerve dysfunction with botulinum toxin
AssigneeMount Sinai School of Medicine of the City University of New York
InventorsIra Sanders, Christopher M. Shaari
Life of this patent
Estimating the term…
Abstract
There is disclosed according to the present invention a method for the control of autonomic nerve function in a mammal comprising administering a therapeutically effective amount of botulinum toxin to the mammal. Preferred embodiments include administering the toxin to control the function of an autonomic nerve which contributes to at least one symptom of rhinorrhea, otitis media, excessive salivation, asthma, COPD, excessive stomach acid secretion, spastic colitis or excessive sweating.
Claims18
A method for the control of autonomic nerve function in a mammal comprising locally administering to cholinergic neurons of the autonomic system of the mammal an amount of botulinum toxin sufficient to cause denervation of the neurons, wherein said denervation results in control of autonomic nerve function in a target tissue or organ innervated by said neurons, wherein the autonomic nerve function includes the function of an autonomic nerve which contributes to at least one symptom of rhinorrhea, otitis media, excessive salivation, asthma, COPD, excessive stomach acid secretion, spastic colitis or excessive sweating.
A method for the alleviation of rhinorrhea in a mammal comprising locally administering botulinum toxin to the nasal cavity of the mammal in an amount sufficient to denervate cholinergic neurons of the autonomic nervous system that control mucous secretion in the nasal cavity.
A method for the alleviation of rhinorrhea in a mammal comprising topically administering botulinum toxin to the nasal mucosa in an amount sufficient to denervate cholinergic neurons of the autonomic nervous system that control mucus secretion into the nasal cavity.
A method for the alleviation of rhinorrhea in a mammal comprising injecting botulinum toxin into the sphenopalatine ganglion in an amount sufficient to denervate cholinergic neurons of the autonomic nervous system that control mucus secretion into the nasal cavity.
Dependencies are inferred from the claim text.