Megakaryocyte production
AssigneeAmgen Inc.
InventorsYee Pang Yung, Karl Welte
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Abstract
A method of increasing megakaryocyte production is disclosed. Such method comprises administering to a mammal a pharmaceutically effective amount of G-CSF and a pharmaceutically effective amount of IL-3 or GM-CSF, and optionally a pharmaceutically effective amount of IL-6. Another method comprises administering GM-CSF and IL-5. Also disclosed are compositions for use in increasing megakaryocyte production. A method of increasing blood platelet production is also disclosed. Such method comprises administering to a mammal a pharmaceutically effective amount of IL-6 and optionally a pharmaceutically effective amount of IL-3, G-CSF or GM-CSF. Also disclosed are compositions for use in increasing blood platelet production.
Claims15
A method of increasing megakaryocyte production in a mammal comprising administering a pharmaceutically effective amount of G-CSF and a pharmaceutically effective amount of G-CSF.
A method as in claim wherein 3 the IL-6 is administering from 0-7 days after G-CSF administration.
A method of increasing megakaryocyte production in a mammal comprising administering a pharmaceutically effective amount of IL-5 and a pharmaceutically effective amount of GM-CSF.
A method of increasing blood platelets in a mammal comprising administering a pharmaceutically effective amount of IL-6 and a pharmaceutically effective amount of G-CSF or GM-CSF.
A method for the treatment of thrombocytopenia in a mammal comprising administering a pharmaceutically effective amount OF G-CSF and a pharmaceutically effective amount of GM-CSF.
A method for the treatment of thrombocytopenia in a mammal comprising administering a pharmaceutically effective amount of IL-5 and a pharmaceutically effective amount of GM-CSF.
A method for the treatment of thrombocytopenia in a mammal comprising administering a pharmaceutically effective amount of IL-6 and a pharmaceutically effective amount of G-CSF or GM-CSF.
Dependencies are inferred from the claim text.