Human neutralizing monoclonal antibodies to respiratory syncytial virus
AssigneeThe Scripps Research Institute
InventorsDennis R. Burton, Carlos F. Barbas, III, Robert M. Chanock, Brian R. Murphy, James E. Crowe, Jr.
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Abstract
Human monoclonal antibodies and fragments thereof which bind and neutralize respiratory syncytial virus (RSV) antigenic subgroups A and B are disclosed. Also disclosed are diagnostic and immunotherapeutic methods of using the monoclonal antibodies as well as cell lines producing the monoclonal antibodies.
Claims29
A human monoclonal antibody that neutralizes both antigenic subgroup A and subgroup B of respiratory syncytial virus (RSV), wherein the antibody binds to an epitope present on glycoprotein F, and has the binding specificity of the antibody Fab fragment produced by ATCC 69702.
A polynucleotide sequence encoding a human monoclonal antibody that neutralizes both antigenic subgroup A and subgroup B of respiratory syncytial virus (RSV), wherein the antibody binds to an epitope present on glycoprotein F and has the binding specificity of the antibody Fab fragment produced by ATCC 69702.
A binding peptide comprising a human epitope-binding amino acid sequence that neutralizes both antigenic subgroup A and subgroup B of respiratory syncytial virus (RSV), wherein the peptide binds to an epitope present on glycoprotein F and has the binding specificity of the antibody Fab fragment produced by ATCC 69702.
A monoclonal antibody fragment produced by ATCC 69072.
Dependencies are inferred from the claim text.