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US 5,760,200 AGranted
Water insoluble derivatives of polyanionic polysaccharides
AssigneeGenzyme Corporation
InventorsRobert J. Miller, Xuejian Xu
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Abstract
A water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a nucleophile, and an activating agent, under conditions sufficient to form the composition. Also, a water insoluble, biocompatible composition that is formed by a method which combines, in an aqueous mixture, a polyanionic polysaccharide, a modifying compound, a nucleophile and an activating agent under conditions sufficient to form the composition.
Claims21
A method of making a water insoluble biocompatible composition, said method comprising combining, in an aqueous mixture,
- (a) a polyanionic polysaccharide at a concentration range between 0.005 to 0.1M, wherein said polyanionic polysaccharide has a molecular weight in the range of 9.0.times.10.sup.4 to 3.0.times.10.sup.6 daltons,
- (b) at least 1 molar equivalent of a nucleophile per molar equivalent of said polyanionic polysaccharide, and
- (c) at least 0.1 molar equivalent of an activating agent per molar equivalent of said polyanionic polysaccharide,
- wherein the reaction is carried out at a pH of 3.5 to 8.0 under conditions sufficient to form said water insoluble biocompatible composition.
1 more element
Dependencies are inferred from the claim text.