Arylhydrazone derivatives useful as antibacterial agents
AssigneeScriptgen Pharmaceuticals, Inc.
InventorsKelvin T. Lam, David G. Powers
Life of this patent
Estimating the term…
Abstract
The subject invention, provides arylhydrazone compounds having the Formula 1: ##STR1## wherein A and B are independently aryl or heteroaryl and A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR.sup.7, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, NO.sub.2, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7, NHCOR.sup.7, NHSO.sub.2 R.sup.7, OR.sup.7, hydroxyalkyl, and aminoalkyl. The compounds of this invention are useful for treating a wide variety of bacterial infections, including diseases of the skin, e.g., acne and skin ulcers, gastroenteritis, colitis, meningitis, keratinitis, conjunctivitis, diseases of the urinary and genital tracts, etc.
Claims19
A compound having Formula l:
- ##STR14## wherein A and B are independently phenyl, naphthyl, pyridyl, pyrazinyl, indolyl, indolinyl, benzofuryl, biphenyl, bipyridyl, phenylpyridyl, pyridylphenyl, benzothienyl, quinolyl or isoquinolyl;
- and
- A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR.sup.7, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, NO.sub.2, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7, NHCOR.sup.7, NHSO.sub.2 R.sup.7, OR.sup.7, hydroxyalkyl, and aminoalkyl;
- R.sup.7 and R.sup.8 are independent hydrogen, alkyl, alkenyl, or haloalkyl;
- W is hydrogen, alkyl, alkanoyl, or cycloalkanoyl;
- X is CN or SO.sub.2 R.sup.7 ;
- pharmaceutically acceptable salts thereof:
- and
- wherein when X is CN, W is H, A is phenyl or phenyl substituted by alkyl, halogen, OR.sup.7, or A is naphthyl, furyl or thienyl, then B is not phenyl, or phenyl substituted by alkyl, halogen, OR.sup.7, CN or NO.sub.2.
A method for treating infections caused by Staphylococcus aureus in a mammal wherein an effective amount of the compound having Formula I:
- ##STR15## wherein A and B are independently phenyl, naphthyl, pyridyl, pyrazinyl, indolyl, indolinyl, benzofuryl, biphenyl, bipyridyl, phenylpyridyl, pyridylphenyl, benzothienyl, quinolyl or isoquinolyl:
- and
- A and B independently are substituted with at least one group selected from alkyl, halogen, CN, COOR.sup.7, NR.sup.7 R.sup.8, CONR.sup.7 R.sup.8, NO.sub.2, SR.sup.7, SOR.sup.7, SO.sub.2 R.sup.7, NHCOR.sup.7, NHSO.sub.2 R.sup.7, OR.sup.7, hydroxyalkyl, and aminoalkyl;
- R.sup.7 and R.sup.8 are independent hydrogen, alkyl, alkenyl, or haloalkyl;
- W is hydrogen, alkyl, alkanoyl, or cycloalkanoyl:
- X is CN, CONR.sup.7 R.sup.8, or SO.sub.2 R.sup.7 ;
- and pharmaceutically acceptable salts thereof:
- is administered to the mammal in need of said treatment.
Dependencies are inferred from the claim text.