Chemotherapy for cancer by inhibiting the fatty acid biosynthetic pathway
AssigneeThe John Hopkins University
InventorsFrancis P. Kuhajda, Gary R. Pasternack
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Abstract
Fatty acid synthase (FAS) is overexpressed in carcinomas with poor prognosis, but little FAS expression is identified in normal tissues Inhibition of fatty acid synthesis is selectively toxic to carcinoma cells, while normal cells with low FAS activity are resistant. This invention provides a method of treating cancer patients where fatty acid synthesis by cells of the patient's tumor is inhibited with resultant interruption of the disease process.
Claims40
A method of inhibiting growth of tumor cells in an animal, said cells expressing at least one enzyme of the fatty acid biosynthetic pathway, comprising administering an inhibitor of fatty acid synthesis to the tumor cells in an amount specifically cytotoxic to said tumor cells,
- wherein the inhibitor of fatty acid synthesis inhibits lipid biosynthesis by a cell as demonstrated by inhibition of growth in vitro of a tumor cell expressing fatty acid synthase (FAS), said inhibition of growth in vitro being reversed by oleate.
A method of inhibiting growth of tumor cells in an animal, said tumor cells expressing a protein exhibiting fatty acid synthase (FAS) activity, comprising administering an inhibitor of fatty acid synthesis to said animal in an amount specifically cytotoxic to said tumor cells,
- wherein the inhibitor of fatty acid synthesis inhibits lipid biosynthesis by a cell as demonstrated by inhibition of growth in vitro of a tumor cell expressing FAS, said inhibition of growth in vitro being reversed by oleate.
A method of inhibiting growth of tumor cells in an animal, said cells expressing at least on enzyme of the fatty acid biosynthetic pathway, comprising
- detecting tumor cells expressing at least one enzyme of fatty acid biosynthetic pathway in said animal, and
- administering an inhibitor of fatty acid synthesis to said animal in an amount specifically cyotoxic to said tumor cells.
- wherein the inhibitor of fatty acid synthesis inhibits growth in vitro of a tumor cell expressing fatty acid synthase (FAS), said inhibition of growth in vitro being reversed by oleate.
Dependencies are inferred from the claim text.