US 5,759,563 A · Liquid delivery compositions

Abstract

Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.

Claims14

Dependent claims

A polymer system suitable for use as a controlled release implant for the controlled release of an active agent, comprising:

a) a solid microporous matrix of a biocompatible, biodegradable, thermoplastic polymer, the polymer being insoluble in an aqueous medium;
and
b) an active agent incorporated into a biodegradable particulate controlled release component, the particulate controlled release component being substantially insoluble in the aqueous medium, and the controlled release component being embedded within the microporous matrix;
wherein the solid microporous matrix is prepared by contact between an aqueous medium and a delivery composition which includes a biocompatible, organic solvent which has a solubility range of miscible to dispersible in an aqueous medium, the biocompatible thermoplastic polymer, and the active agent incorporated into the biodegradable, particulate controlled release component.

1 more element

A biodegradable microporous film dressing having a skin and a core, wherein the skin has pores with a substantially smaller diameter than the core, and wherein the film dressing is formed from a delivery composition comprising:

(a) a biocompatible, biodegradable thermoplastic polymer which is insoluble in aqueous medium;
(b) a biocompatible organic solvent which has a solubility range of miscible to dispersible in aqueous medium;
and
(c) an active agent incorporated into a biodegradable particulate controlled release component, the particulate controlled release component being substantially insoluble in the aqueous medium and the controlled release component.

1 more element

Dependencies are inferred from the claim text.

Liquid delivery compositions

Life of this patent

Liquid delivery compositions

Life of this patent

Abstract

Claims14