Back to results
US 5,759,550 AGranted
Method for suppressing xenograft rejection
AssigneePharmagenesis, Inc.
InventorsTien Wen Tao Wiedmann, Jian Wang
Life of this patent
Estimating the term…
Abstract
An improved method for suppressing xenograft rejection in a host subject is disclosed. The method includes administering an immunosuppressant drug, where the drug or the amount of drug administered is, by itself, ineffective to suppress xenograft rejection. Effective xenograft suppression is achieved by also administering an ethanolic extract of Triterygium wilfordii or a purified triptolide component thereof.
Claims10
A method of suppressing xenograft rejection in a host subject, comprising
- administering to the subject, an immunosuppressant drug selected from the group consisting of cyclosporin A, FK506, azathioprine, rapamycin, mycophenolic acid, a gluco-corticoid, and cyclophosphamide, where the drug or amount of drug administered is, by itself, ineffective to suppress xenograft rejection in the subject, and
- administering to the subject a potentiator selected from the group consisting of (i) an ethanolic extract of Triterygium wilfordii and a (ii) purified triptolide component of said extract, in an amount effective to suppress xenograft rejection in the host in combination with the immunosuppressant drug.
Dependencies are inferred from the claim text.