Antibody-containing oral composition for suppression of periodontal disease
AssigneeLion Corporation
InventorYoshihiro Harada
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Abstract
An oral composition comprises an effective amount of an antibody obtained by immunizing an animal with an antigen comprised of at least one polysaccharide derived from the surface layer of periodontal disease associated bacteria. The at least one polysaccharide may be conjugated with polypeptides to further enhance the efficacy.
Claims19
An oral composition in the form of a dentifrice, which comprises an antibody obtained by immunizing an animal with an antigen that consists of at least one polysaccharide derived from the surface layer of Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis, and a pharmaceutically acceptable carrier.
An oral composition in the form of a dentifrice, which comprises an antibody obtained by immunizing an animal with an antigen conjugated with a polypeptide that can increase antibody titer in a mammal with respect to a polysaccharide when conjugated with said polysaccharide, wherein said antigen consists of at least one polysaccharide derived from the surface layer of Actinobacillus actinomycetemcomitans or Porphyromonas gingivalis, and a pharmaceutically acceptable carrier.
An oral composition in the form of a dentifrice, which comprises an antibody obtained by immunizing an animal with an antigen consisting of at least one polysaccharide selected from the group consisting of polysaccharides of formulas (a), (b), and (c):
- ##STR3## wherein Ac represents an acetyl group and n is an integer of from 1 to 1,000, and a pharmaceutically acceptable carrier.
An oral composition in the form of a dentifrice, which comprises an antibody obtained by immunizing an animal with an antigen-polypeptide conjugate,
- wherein said antigen consists of the polysaccharide of formula (b):
- ##STR4## wherein n is an integer of from 1 to 1,000, and wherein said polypeptide increases antibody titer with respect to said polysaccharide antigen (b), and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.