Neural regeneration using human bone morphogenetic proteins
AssigneeGenetics Institute, Inc.
InventorsElizabeth A. Wang, Josephine S. D'Alessandro, Dean M. Toriumi
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Abstract
Methods and devices are disclosed for inducing growth of neural cells, and repairing neural defects in a mammal. The method comprises administering to said mammal at the site of neural defect, damage or depletion, an effective amount of a bone morphogenetic protein, either in admixture with a pharmaceutically acceptable vehicle, or adsorbed to a suitable matrix. The device comprises bone morphogenetic protein, optionally in combination with other factors, adsorbed on a suitable matrix and contained within an artificial nerve replacement vessel.
Claims17
A nerve replacement device comprising an artificial nerve replacement vessel which contains a composition comprising a bone morphogenetic protein in an amount sufficient to promote the growth of astrocyes and a suitable matrix carrier, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
A method of inducing formation of astrocytes in a suitable cell population which method comprises administering to said cell population an effective amount of a bone morphogenetic protein in admixture with a pharmaceutically acceptable vehicle, said bone morphogenetic protein being selected from the group consisting of BMP-2, BMP-4, BMP-5, BMP-6, BMP-7 and heterodimers of BMP-2/6 and BMP-2/7.
Dependencies are inferred from the claim text.