Adenoviruses having modified fiber proteins
AssigneeGenetic Therapy, Inc.
InventorsAlan McClelland, Susan C. Stevenson
Life of this patent
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Abstract
An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be "targeted" in order to deliver such gene(s) to a desired cell type.
Claims14
A method of expressing a therapeutic agent in an animal, comprising:
- administering to an animal an adenovirus wherein the adenovirus fiber includes a ligand which is specific for a receptor located on a desired cell type, and wherein said adenovirus includes at least one DNA sequence encoding a therapeutic agent.
A method of expressing a therapeutic agent in a eukaryotic cell, comprising:
- transducing a eukaryotic cell with an adenovirus wherein the adenovirus fiber includes a ligand which is specific for a receptor located on a desired cell type, and wherein said adenovirus includes at least one DNA sequence encoding a therapeutic agent.
An adenovirus wherein at least a portion of the adenovirus fiber protein is removed and replaced with a ligand which is a member of the TNF superfamily of ligands.
Dependencies are inferred from the claim text.