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US 5,753,664 AGranted
Heterocyclic compounds, their production and use
AssigneeTakeda Chemical Industries, Ltd.
InventorsTetsuya Aono, Shogo Marui, Fumio Itoh, Masuo Yamaoka, Masafumi Nakao
Life of this patent
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Abstract
A novel compound of the formula: A--Z--Ar.sup.1 1'CO--Ar.sup.2 wherein A is a condensed pyrimidinone or condensed pyridazinone ring; Ar.sup.1 and Ar.sup.2 are independently a ring; Z is a divalent group, or a salt thereof which have an excellent antitumor activity.
Claims6
A compound of the formula:
- ##STR25## wherein A is the formula:
- ##STR26## wherein A.sup.1 is pyridine ring or piperidine ring which may be substituted with methyl and R.sup.1 is methyl;
- Z is --O--CH.sub.2 ;
- R is halogen, C.sub.1-6 alkyl, halo-C.sub.1-6 alkyl, C.sub.1-6 alkoxy, or halo-C.sub.1-6 alkoxy, or a salt thereof.
1 more element
3-Methyl-2-4-(4-trifluoromethylbenzoyl )benzyloxy!-6,7,8,9-tetrahydro-4H-pyrido1,2-a!pyrimidin-4-one, or a salt thereof.
Dependencies are inferred from the claim text.