Carboxyalkylethers, formulations, and treatment of vascular diseases

A method for lowering apolipoprotein B comprising administering to a mammal an effective amount of a compound of the formula ##STR14## wherein n and m independently are integers from 2 to 9;

• R.sub.1, R.sub.2, R.sub.3, and R.sub.4 independently are C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, and R.sub.1 and R.sub.2 together vith the carbon to which they are attached, and R.sub.3 and R4 together with the carbon to which they are attached, independently can complete a carbocyclic ring having from 3 to 6 carbons;
• Y.sub.1 and Y.sub.2 independently are COOH, CHO, tetrazole, and COOR.sub.5 where R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 aIkynyl;
• and where the alkyl, alkenyl, and alkynyl groups may be substituted with one or two groups selected from halo, hydroxy, C.sub.1 -C.sub.6 alkoxy, and phenyl, and the pharmaceutically acceptable salts thereof.

A method of elevating plasma apolipoprotein A-1 comprising administering to a mammal an effective amount of a compound of the formula ##STR15## wherein n and m independently are integers from 2 to 9;

• R.sub.1, R.sub.2, R.sub.3 and R.sub.4 independently are C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, and R.sub.1 and R.sub.2 together with the carbon to which they are attached, and R.sub.3 and R.sub.4 together with the carbon to which they are attached, independently can complete a carbocyclic ring having from 3 to 6 carbons;
• Y.sub.1 and Y.sub.2 independently are COOH, CHO, tetrazole , and COOR.sub.5 where R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl;
• and where the alkyl, alkenyl, and alkynyl groups may be substituted with one or two groups selected from halo, hydroxy, C.sub.1 -C.sub.6 alkoxy, and phenyl, and the pharmaceutically acceptable salts thereof.

A method of elevating plasma apolipoprotein E comprising administering an effective amount of a compound of the formula ##STR16## wherein n and m independently are integers from 2 to 9;

• R.sub.1, R.sub.2, R.sub.3, and R.sub.4 independently are C.sub.1 -C.sub.6 alyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, and R.sub.1 and R.sub.2 together with the carbon to which they are attached and R.sub.3 and R.sub.4 together with the carbon to which they are attached, indeperdently can complete a carbocyclic ring having fom 3 to 6 carbons;
• Y.sub.1 and Y.sub.2 independently are COOH, CHO, tetrazole, and COOR.sub.5 where R.sub.5 is C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl , C.sub.2 -C.sub.6 alkynyl;
• and where the alkyl, alkeny, and alkynyl groups may be substituted with one or two groups selected from halo, hydroxy, C.sub.1 -C.sub.6 alkoxy, and phenyl, and the pharmaceuticaliy acceptable salts thereof.