Antibodies to .beta.-amyloids or their derivatives and use thereof
AssigneeTakeda Chemical Industries, Ltd.
InventorsNobuhiro Suzuki, Asano Odaka, Chieko Kitada
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Abstract
According to this invention, antibodies which are useful and novel in that they have binding specificity to .beta.-amyloids or derivatives thereof, namely recognize the N-terminal, the C-terminal or central portions of the .beta.-amyloids, respectively, were obtained. By combining these antibodies, determination methods by which the .beta.-amyloids could be determined sensitively and specifically are provided. These determination methods are useful for diagnosis of diseases to which the .beta.-amyloids or their derivatives are related (for example, Alzheimer's disease), and the antibodies of this invention are useful for the development of preventive-therapeutic compositions for Alzheimer's disease.
Claims9
An antibody specifically reactive to a peptide on the C-terminal side of a .beta.-amyloid comprising the amino acid sequence of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 or SEQ ID NO:6 or a derivative thereof which is a peptide lacking 1 to 17 amino acid residues from the N-terminal portion of the said .beta.-amyloid, a peptide in which L-aspartic acid of the said .beta.-amyloid is isomerized to L-isoaspartic acid, D-isoaspartic acid or D-aspartic acid, and a peptide in which the N-terminal portion of the said .beta.-amyloid has pyroglutamic acid, and, in which said antibody does not recognize a peptide comprising the amino acid sequence of SEQ ID NO:7.
Dependencies are inferred from the claim text.