Delivery of nucleotides into organisms by electroporation
AssigneeMassachusetts Institute of Technology
InventorsThomas E. Zewert, Uwe Pliquett, Robert S. Langer, James C. Weaver
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Abstract
A method for delivering a nucleotide into an organism includes applying a composition which includes a nucleotide component to epidermis of the organism. The epidermis is electroporated, whereby at least a portion of the composition enters or passes across the epidermis, thereby delivering the nucleotide into the organism. An example of a suitable nucleotide which can be delivered by the method of the invention includes antisense oligodeoxynucleotides for treatment of melanomas.
Claims49
A method for delivering a nucleotide component of a composition into an organism, comprising:
- a) applying the compositions which includes the nucleotide components to stratum corneum of the organism, whereby said nucleotide component directly contacts said stratum corneum;
- and thereafter
- b) electroporating the stratum corneum, whereby at least a portion of the composition enters or passes across the stratum corneum, thereby delivering the nucleotide component into the organism.
Dependencies are inferred from the claim text.