Chitosan-derived biomaterials
AssigneeWound Healing of Oklahoma
InventorsRobert E. Nordquist, Wei R. Chen, Raoul Carubelli, Robert Adams
Life of this patent
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Abstract
Chitosan-derived biomaterials, and, more specifically, chitosan modified by the addition of a monosaccharide or oligosaccharide side chain to its free amino groups. The modified chitosan ("glycated chitosan") is preferably stabilized by reduction. In one particularly preferred embodiment, a galactose derivative of chitosan ("galacto-chitosan") is provided. The chitosan-derived biomaterials are useful in a myriad of biomedical applications, including as an immunoadjuvant in laser/sensitizer assisted immunotherapy.
Claims19
An immunoadjuvant comprising a suspension or a solution of glycated chitosan.
An immunoadjuvant consisting essentially of glycated chitosan.
A chitosan-derived biomaterial comprising a linear homopolymer of deacetylated chitin (chitosan), said deacetylated chitin having a number of otherwise free amino groups bonded to a carbonyl group of a reducing monosaccharide or oligosaccharide to form glycated chitosan.
A composition for use in conditioning a neoplasm for tandem photophysical and immunologic treatment, comprising a combination of a chromophore and an immunoadjuvant, wherein the chromophore and the immunoadjuvant are conjugated to a tumor specific antigen, and wherein the immunoadjuvant is glycated chitosan.
A composition for use in conditioning a neoplasm for tandem photophysical and immunologic treatment, comprising a combination of a chromophore and an immunoadjuvant, wherein the chromophore and the immunoadjuvant are conjugated to a tumor specific antibody, and wherein the immunoadjuvant is glycated chitosan.
An injectable solution for conditioning a neoplasm for tandem photophysical and immunologic treatment comprising a mixture of a chromophore and an immunoadjuvant wherein the immunoadjuvant is glycated chitosan.
Dependencies are inferred from the claim text.