Prolonged local anesthesia with colchicine
AssigneeEuro-Celtique S.A.
InventorsRichard Sackler, Paul Goldenheim, Mark Chasin
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Abstract
A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible nerve blockade when implanted or injected in a patient, and an amount of colchicine effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without colchicine.
Claims33
A formulation for inducing sustained regional local anesthesia in a patient comprising
- a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable controlled release material prolonging the release of said local anesthetic from said substrate to obtain a reversible nerve blockade when implanted or injected in a patient, and
- an amount of colchicine effective to prolong the duration of said local anesthesia for a time period longer than that obtainable from the substrate without said colchicine.
A formulation for inducing sustained regional local anesthesia in a patient comprising
- a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material for prolonging the release of said local anesthetic from said substrate to obtain a reversible nerve blockade when implanted or injected in a patient, and
- an amount of colchicine effective to prolong the duration of said local anesthesia, said formulation providing an in vitro release of said local anesthetic of from about 10 to about 60 percent after 24 hours, from about 20 to about 80 percent release after 48 hours and from about 40 to about 100 percent release after 72 hours, said formulation providing a reversible nerve blockade at the site when administered in vivo of at least about 24 hours.
A controlled release formulation for inducing sustained regional local anesthesia at a site in a patient comprising
- a local anesthetic incorporated in a controlled release formulation consisting essentially of a biocompatible material, said material degrading at least fifty percent in less than six months following implantation into a patient, wherein the local anesthetic is present in a concentration effective to achieve local anesthesia in the patient, and an amount of colchicine effective to prolong the duration of the local anesthesia.
A method for inducing sustained regional local anesthesia at a site in a patient, comprising:
- preparing a local anesthetic in a biocompatible, biodegradable controlled release form such that the percent release of said local anesthetic in vivo is from about 10 to about 60 percent release after 24 hours, from about 20 to about 80 percent after 48 hours, and from about 40 to about 100 percent release after 72 hours,
- administering an effective amount of said local anesthetic in controlled release form to achieve a reversible nerve blockade at the site, and administering an amount of colchicine at the site, that is effective to achieve a reversible nerve blockade at the site for at least about 24 hours.
Dependencies are inferred from the claim text.