Aerosols containing beclomethazone nanoparticle dispersions
AssigneeNanoSystems L.L.C.
InventorsTimothy S. Wiedmann, Ray W. Wood, Lan DeCastro
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Abstract
There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethazone particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment using the aerosol.
Claims10
An aerosol of an aqueous dispersion of nanoparticles, wherein the nanoparticles comprise 0.1 to 60% (w/w) of insoluble beclomethasone particles having (1) an average particle size of less than about 400 nm, and (2) 0.1 to 90% (w/w) of a surface modifier adsorbed on the surface thereof.
A method for forming an aerosol of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble beclomethasone particles comprising:
- a) providing an aqueous suspension of nanoparticles, wherein the nanoparticles comprise 0.1 to 60% (w/w) of insoluble beclomethasone particles having (1) an average particle size of less than about 400 nm, and (2) 0.1 to 90% (w/w) of a surface modifier adsorbed on the surface thereof;
- and
- b) nebulizing said suspension so as to form an aerosol.
A method of treating a respiratory related illness of a mammal comprising:
- administering an effective amount of an aerosol comprising an aqueous dispersion of nanoparticles, wherein said nanoparticles comprise 0.1 to 60% (w/w) of insoluble beclomethasone particles having (1) an average particle size of less than about 400 nm, and (2) 0.1 to 90% of a surface modifier adsorbed on the surface thereof, wherein droplets of the aerosol deposit in the respiratory tract of the mammal.
Dependencies are inferred from the claim text.