Silver-based pharmaceutical compositions
OwnerChristopher C. Capelliinventor
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Abstract
The present invention relates to pharmaceutical compositions which are photostable and antimicrobially active comprising one or more medicinal agents and a stabilized ionized silver-based antimicrobial composition. The stabilized ionized silver-based antimicrobial composition comprises a stabilizing acyclic polyether polymer, cations, and anions present in excess with regard to the amount of cations. Methods for making and using the pharmaceutical compositions are also described. These pharmaceutical compositions are useful in the prevention and treatment of infections and diseases.
Claims23
A pharmaceutical mixture, comprising:
- a) a non-silver-containing medicinal agent;
- and
- b) a silver ion-containing composition, said silver containing composition comprising an acyclic polyether polymer and a stabilizing anion, wherein said acyclic polyether polymer is selected from the group consisting of polyethylene glycol and polypropylene glycol, wherein said anion is selected from the group consisting of chloride, bromide, and iodide, and wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1 when said anion is chloride, is greater than 2.1 to 1 when said anion is bromide, and is greater than 1.1 to 1 when said anion is iodide, wherein said pharmaceutical mixture is photostable after 72 hours of continuous exposure to ambient room light.
A pharmaceutical mixture, comprising:
- a) a non-silver-containing antimicrobial agent;
- b) a composition comprising:
- i) a stabilizing acyclic polyether polymer wherein said acyclic polyether polymer is selected from the group consisting of polyethylene glycol and polypropylene glycol;
- ii) silver ion, wherein said silver ion is present in an amount ranging from 1.times.10.sup.-6 to 1 meq of silver ion per gram of said acyclic polyether polymer;
- iii) a stabilizing anion wherein said anion is selected from the group consisting of chloride, bromide, and iodide, and wherein the ratio of equivalents of said anion to equivalents of said silver ion is greater than 4 to 1 when said anion is chloride, is greater than 2.1 to 1 when said anion is bromide, and is greater than 1.1 to 1 when said anion is iodide;
- and wherein said pharmaceutical mixture is photostable after 72 hours of continuous exposure to ambient room light.
A method of treating a device, comprising:
- a) providing:
- i) a medical device;
- and
- ii) a pharmaceutical mixture that is photostable after 72 hours of continuous exposure to ambient room light, comprising a non-silver-containing medicinal agent and a composition comprising a stabilizing acyclic polyether polymer wherein said acyclic polyether polymer is selected from the group consisting of polyethylene glycol and polypropylene glycol, a silver ion wherein said silver ion is present in an amount ranging from 1.times.10.sup.-6 meq of silver ion per gram of said acyclic polyether polymer, and a stabilizing anion selected from the group consisting of chloride, bromide, and iodide;
- and
- b) applying said pharmaceutical mixture to said medical device, thereby treating said device.
Dependencies are inferred from the claim text.