Flavivirus recombinant poxvirus immunological composition
AssigneeVirogenetics Corporation
InventorsEnzo Paoletti, Steven Elliot Pincus
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Abstract
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from flavivirus, such as Japanese encephalitis virus, yellow fever virus and Dengue virus. In a preferred embodiment, the recombinant poxvirus generates an extracellular particle containing flavivirus E and M proteins capable of inducing neutralizing antibodies, hemagglutination-inhibiting antibodies and protective immunity against flavivirus infection. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
Claims17
A recombinant poxvirus comprising DNA coding for at least one flavivirus structural protein, wherein the flavivirus is Yellow Fever virus or Dengue virus and the poxvirus is selected from the group consisting of:
- an avipox virus,
- a vaccinia virus wherein the open reading frames for the thymidine kinase gene, a hemorrhagic region, an A type inclusion body region, a hemagglutinin gene, a host range gene region and a large subunit, ribonucleotide reductase have been deleted therefrom,
- a vaccinia virus wherein regions C7L-K1L, J2R, B13R+B14R, A26L, A56R, and I4L have been deleted therefrom, and
- a NYVAC vaccinia virus.
Dependencies are inferred from the claim text.