Flavivirus recombinant poxvirus vaccine
AssigneeVirgenetics Corporation
InventorsEnzo Paoletti, Steven Elliot Pincus
Life of this patent
Estimating the term…
Abstract
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from flavivirus, such as Japanese encephalitis virus, yellow fever virus and Dengue virus. In a preferred embodiment, the recombinant poxvirus generates an extracellular particle containing flavivirus E and M proteins capable of inducing neutralizing antibodies, hemagglutination-inhibiting antibodies and protective immunity against flavivirus infection. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine.
Claims16
A recombinant avipox virus comprising DNA coding for Japanese encephalitis virus protein M or a precursor to protein M, and Japanese encephalitis virus protein E, NS1 and NS2A, in a nonessential region of the avipox genome.
A recombinant avipox virus comprising DNA from Japanese encephalitis virus (JEV) in a nonessential region of the avipox genome, wherein the DNA comprises the part of the JEV open reading frame extending from prM to NS2a.
Dependencies are inferred from the claim text.