Transgenic bovine
AssigneePharming B.V.
InventorsHerman A. Deboer, Rein Strijker, Herbert L. Heyneker, Gerard Platenburg, Sang He Lee, Frank Pieper, Paul J. A. Krimpenfort
Life of this patent
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Abstract
A transgenic bovine is disclosed whose somatic and germ cells contain a transgene, wherein the transgene comprising a mammary gland specific promoter, a mammary gland specific enhancer, a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells and a DNA sequence encoding a heterologous polypeptide of interest wherein the transgenic bovine expresses the transgene such that the polypeptide of interest is detectable in milk produced by the transgenic bovine.
Claims36
A transgenic bovine whose somatic and germ cells contain a transgene, wherein the transgene comprises in operable association:
- a mammary gland specific promoter;
- a mammary gland specific enhancer;
- a DNA sequence encoding a signal sequence functional in bovine mammary gland secretory cells;
- and
- a DNA sequence encoding a heterologous polypeptide of interest;
- wherein the transgenic bovine or a female descendant of the transgenic bovine expresses the transgene in mammary secretory cells such that the polypeptide of interest is detectable in milk produced by the transgenic bovine or a female descendant of the transgenic bovine.
Dependencies are inferred from the claim text.