Controlled release pilocarpine delivery system
AssigneeOramed Ltd.
InventorRamesh N. Acharya
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Abstract
There is disclosed a method for treating a patient suffering from xerostomia, xerophthalmia or excessive intraocular pressure. The method comprises administering to said patient a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof, in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours. Controlled release unit dosage forms containing pilocarpine are also disclosed.
Claims8
A method for treating a patient suffering from xerostomia, comprising orally administering to said patient an extended release formulation comprising a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable extended release carries in an amount sufficient to maintain a blood serum level of pilocarpine in said patient of from about 5 to about 40 ng/ml, for a period of at least 6 hours.
A formulation in unit dosage form comprising an intimate admixture of pilocarpine and calcium polycarbophil, wherein from about 5 to about 30 mg of pilocarpine is present and the ratio of calcium polycarbophil to pilocarpine is from about 10:1 to about 20:1.
Dependencies are inferred from the claim text.