Pyridyl and naphthyridyl compounds for inhibiting osteoclast-mediated bone resorption
AssigneeMerck & Co., Inc.
InventorsGeorge D. Hartman, Mark E. Duggan, William F. Hoffman, Nathan C. Ihle
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Abstract
Compounds of the following general structure X-Y-Z-Aryl-A-B, for example, ##STR1## which inhibit osteoclast mediated bone resorption. Specifically, the compounds are useful for treating mammals suffering from a bone condition caused or mediated by increased bone resorption, who are in need of such therapy. The compounds may be administered in oral dosage forms such as tablets, capsules, e.g. sustained release capsules, powders, granules, and suspensions.
Claims8
A compound of the formula ##STR114## and pharmaceutically acceptable salts thereof, wherein X is selected from the group consisting of ##STR115## Y is selected from the group consisting of C.sub.1-8 alkylene,
- (CH.sub.2)m--C.tbd.C(CH.sub.2)n,
- (CH.sub.2)mCR.sup.1 =CR.sup.2 (CH.sub.2)n,
- (CH.sub.2)mCR.sup.1 =CR.sup.2 (CH.sub.2)n.sup.O,
- C.sub.0-8 alkylene--NR.sup.3 --CO--C.sub.0-8 alkylene,
- C.sub.0-8 alkylene--O--C.sub.0-8 alkylene,
- C.sub.0-8 alkylene-NR.sup.3 --C.sub.0-8 alkylene and
- C.sub.0-8 alkYlene-NR.sup.3 --C.sub.0-8 alkylene--O--;
- A is selected from the group consisting of ##STR116## B is ##STR117## R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each independently selected from the group consisting of
- hydrogen,
- C.sub.1-4 alkoxy C.sub.0-6 alkylene,
- C.sub.1-4 alkoxycarbonyl C.sub.0-6 alkylene,
- C.sub.1-6 alkylamino C.sub.0-8 alkylene,
- C.sub.1-6 dialkylamino C.sub.0-8 alkylene,
- amino C.sub.0-8 alkylene and
- aryl C.sub.0-8 alkylene;
- R.sup.5 is selected from the group consisting of
- hydrogen,
- C.sub.1-4 alkoxy C.sub.0-6 alkylene,
- C.sub.1-4 alkoxycarbonyl C.sub.0-6 alkylene,
- C.sub.1-6 alkylamino C.sub.0-8 alkylene,
- C.sub.1-6 dialkylamino C.sub.0-8 alkylene,
- amino C.sub.0-8 alkylene,
- oxo and
- aryl C.sub.0-8 alkylene;
- R.sup.6 and R.sup.7 are each independently selected from the group consisting of:
- hydrogen,
- C.sub.0-6 alkylamino C.sub.0-6 alkylene,
- C.sub.0-6 dialkylamino C.sub.0-6 alkylene,
- aryl C.sub.0-6 alkyloxycarbonylamino C.sub.0-6 alkylene,
- aryl C.sub.0-6 alkylsulfonylamino C.sub.0-6 alkylene,
- camphorsulfonylamino, and
- aryl C.sub.0-6 alkylcarbonylamino C.sub.0-6 alkylene;
- R.sup.12 is selected from the group consisting of
- hydroxy,
- C.sub.1-8 alkyloxy,
- C.sub.1-6 dialkylaminocarbonylmethoxy and
- aryl C.sub.1-6 dialkylaminocarbonylmethoxy;
- and
- m and n are integers independently chosen from 0-6;
- and the pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.