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US 5,741,524 AGranted
Sustained-release formulations utilizing pharmaceutical excipient having improved compressibility
AssigneeEdward Mendell Co., Inc.
InventorsJohn N. Staniforth, Bob E. Sherwood, Edward A. Hunter
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Abstract
Sustained release formulations include an augmented microcrystalline cellulose, an active agent, and a sustained release carrier and methods for making same are disclosed.
Claims30
A sustained-release formulation comprising:
- an active agent;
- an augmented microcrystalline cellulose comprising agglomerated particles of microcrystalline cellulose and a compressibility augmenting agent which
- (i) physically restricts the proximity of the interface between adjacent cellulose surfaces, (ii) inhibits interactions between adjacent cellulose surfaces;
- or (iii) accomplishes both (i) and (ii) above;
- and a matrix comprising a sustained-release carrier to promote sustained-release of said active agent.
2 more elements
Dependencies are inferred from the claim text.