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US 5,739,386 AGranted
Photolabile compounds and methods for their use
AssigneeAffymax Technologies N.V.
InventorChristopher P. Holmes
Life of this patent
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Abstract
Novel compounds are provided which are useful as photocleavable linking groups in solid phase synthesis. Compositions incorporating these linking groups and methods for their use are also described.
Claims7
A compound having the formula:
- ##STR18## wherein, R.sup.1 is hydrogen, C.sub.1 -C.sub.8 alkyl, aryl or arylalkyl;
- R.sup.2, R.sup.3 and R.sup.4 are each independently hydrogen, C.sub.1 -C.sub.8 alkyl, or C.sub.1 -C.sub.8 alkoxy;
- X.sup.11 is selected from the group consisting of halogen, --NH.sub.2, --NHP, in which P is a suitable protecting or activating group, and --NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aryl alkyl, substituted aryl alkyl, heteroaryl, and substituted heteroaryl and Y.sup.11 is selected from the group consisting of halogen, --SH, --SP, OH, --OP, --NH.sub.2, --NHP, in which P is a suitable protecting or activating group, and --NR.sup.5 R.sup.6 wherein R.sup.5 and R.sup.6 are independently selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, aryl alkyl, substituted aryl alkyl, heteroaryl, and substituted heteroaryl;
- and q is an integer of from 1 to 10.
1 more element
Dependencies are inferred from the claim text.