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US 5,739,277 AGranted
Altered polypeptides with increased half-life
AssigneeGenentech, Inc.
InventorsLeonard G. Presta, Bradley R. Snedecor
Life of this patent
Estimating the term…
Abstract
Polypeptides that are cleared from the kidney and do not contain in their original form a Fc region of an IgG are altered so as to comprise a salvage receptor binding epitope of an Fc region of an IgG and thereby have increased circulatory half-life.
Claims3
A polypeptide that is not an Fc fragment comprising the sequences HQNLSDGK (SEQ ID NO:
- 1) and PKNSSMISNTP (SEQ ID NO:
- 3).
A polypeptide that is not an Fc fragment comprising the sequences
- HQNISKGK (SEQ ID NO:
- 2) and PKNSSMISNTP (SEQ ID NO:
- 3).
A polypeptide that is not an Fc fragment comprising the sequences VISSHLGQ (SEQ ID NO:
- 31) and PKNSSMISNTP (SEQ ID NO:
- 3).
Dependencies are inferred from the claim text.